岳学田，博士，研究员

教育经历：

2009.9-2012.6 山东大学，免疫学博士

2006.9-2009.4 浙江理工大学，生化与分子生物学硕士

2001.9-2005.7 聊城大学，生物工程学士

工作经历：

2018.3-至今 山东大学，基础医学院，研究员

2013.1-2018.1 美国罗格斯大学，新泽西肿瘤研究中心，博士后

 研究方向：

1.肿瘤免疫；

2.肿瘤代谢。

发表代表性论文：

1. Yue X, Zhang C, Zhao Y, Liu J, Lin AW, Tan VM, Drake JM, Liu L, Boateng MN, Li J, Feng Z*, Hu W*. Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. Genes Dev. 2017 Aug 15;31(16):1641-1654. doi: 10.1101/gad.301564.117.

2. Yue X, Zhao Y, Xu Y, Zheng M, Feng Z*, Hu W*. Mutant p53 in cancer: Accumulation, gain-of-function and therapy. J Mol Biol. 2017 Apr 5. pii: S0022-2836(17)30163-8. doi: 10.1016/j.jmb.2017.03.030.

3. Yue X, Zhao Y, Huang G, Li J, Zhu J, Feng Z, Hu W*. A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis. Cell Discov. 2016 Nov 1;2:16039. eCollection 2016.

4. Yue X, Zhan Y, Zhang C, Li Jun, Liu Z, Liu J, Hu W*. LeLeukemia Inhibitory Factor Promotes EMT through STAT3-dependent miR-21 induction. Oncotarget .2016 Jan 26; 7(4):3777-90.

5. Yue X, Zhao Y, Liu J, Zhang C, Yu H, Wang J, Zheng T, Liu L, Li J, Feng Z*, Hu W*. BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function. Elife. 2015. 4: e08401.

6. Yue X, Zhang Z, Liang X, Gao L, Zhang X, Zhao D, Liu X, Ma H, Guo M, Spear BT, Gong Y, Ma C*. Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression of Cyclins A and E. Gastroenterology. 2012. 142: 1559-1570.

7. Ma H, Yue X (co-first author), Gao L, Liang X, Yan W, Zhang Z, Shan H, Zhang H, Spear BT, Ma C*. ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA. Oncotarget. 2015. 6:1049-1063.

8. Liu J, Zhang C, Zhao Y, Yue X, Wu H, Huang S, Chen J, Tomsky K, Xie H, Khella CA, Gatza ML, Xia D, Gao J, White E, Haffty BG, Hu W*, Feng Z*. Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. Nat Commun. 2017 Nov 28;8(1):1823. doi: 10.1038/s41467-017-01947-w.

9. Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, Li J, Zhu J, Shen Z, Haffty BG, Hu W*, Feng Z*.Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes Dev. 2016 Sep 1;30(17):1956-70.

10. Zhang C, Liu J, Zhao Y, Yue X, Zhu Y, Wang X, Wu H, Blanco F, Li S, Bhanot G, Haffty BG, Hu W*, Feng Z*. Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. Elife. 2016 Jan 11; 5:e10727.

11. Zhao Y, Zhang C, Yue X, Li X, Liu J, Yu H, Belyi VA, Yang Q, Feng *Z, Hu W*. Pontin, a new mutant p53 binding protein, promotes gain of function of mutant p53. Cell Death and Differentiation. 2015. 22: 1824-1836.

12. Luan F, Liu P, Ma H, Yue X, Liu J, Gao L, Liang X, Ma C*. Reduced nucleic ZHX2 involves in oncogenic activation of glypican 3 in human hepatocellular carcinoma. The International Journal of Biochemistry & Cell Biology. 2014. 55: 129-135.

13. Yu H, Yue X, Zhao Y, Li X, Wu L, Zhang C, Liu Z, Lin K, Xu-Monette ZY, Young KH, Liu J, Shen Z, Feng Z*, Hu W*. LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nature Communications. 2014. 5: 5218.

联系方式：

E-mail：yuexu@sdu.edu.cn