王晓静,博士,副教授,硕士生导师
学习经历:
1992.9-1996.7 山东师范大学生物系学习,获理学学士学位。
1996.9-1999.7 山东师范大学动物学专业硕士,导师艾洪滨教授。
2001.9-2004.7 山东大学生理学专业博士,导师张衡教授。
工作经历:
2014.9-至今 山东大学副教授
2001.9-2014.8 山东大学医学院 讲师
2006.1-2009.2 美国密西根大学和印第安那大学医学院博士后
2002.10-2004.4 北京大学生命科学院联合培养博士生
1999.7-2001.9 山东医科大学 助教
教学工作:
承担本科生《细胞生物学》、《细胞生物学实验》,研究生《细胞生物学进展》、《细胞生物学技术》,留学生全英语《Cell Biology》的教学工作。教学效果优秀,曾在院校组织的青年教师讲课中多次获奖,参与或主持多项省部级教学改革项目,参加出版多部规划教材的编写工作,指导完成大学生创新性实验计划项目多项,并曾获得山东大学大学生科技创新基金一、二、三等奖。
研究兴趣:
1. 神经损伤修复及神经再生
2. 神经炎症
主持的科研项目:
1. 82471420,TIPE1下调Ras蛋白棕榈酰化修饰抑制小胶质细胞炎症反应减轻缺血性脑卒中损伤的作用机制研究,国家自然科学面上基金,2025-2028,49万,主持人
2. ZR2021MH205,ZHX2在神经再生中的作用及机制研究,山东省自然科学基金,2022-2024,10万,主持人
3. ZR2017MH058,绞股蓝皂苷对酒精损伤神经干细胞的保护及机制研究,山东省自然科学基金,2017-2020,12万,主持人
代表性成果:
1. Xue Xia; Jiahao Chen; Haiyuan Ren; Chang Zhou; Qingli Zhang; Haoyang Cheng; Xiaojing Wang ; Gypenoside Pretreatment Alleviates the Cerebral Ischemia Injury via Inhibiting the MicrogliaMediated Neuroinflammation, Molecular Neurobiology, 2024.2, 61: 1140-1156 (唯一通讯作者)
2. Haiyuan Ren; Jinrui Li; Ai Peng; Ting Liu; Mengjun Chen; Hongguang Li; Xiaojing Wang; Water-Soluble, Alanine-Modified Fullerene C60 Promotes the Proliferation and Neuronal Differentiation of Neural Stem Cells, International Journal of Molecular Sciences, 2022, 23(10): 5714-5714 (共同通讯作者 )
3. Liu, Xingyu; Ren, Haiyuan; Peng, Ai; Cheng, Haoyang; Chen, Jiahao; Xia, Xue; Liu, Ting; Wang, Xiaojing ; The Effect of RADA16-I and CDNF on Neurogenesis and Neuroprotection in Brain Ischemia-Reperfusion Injury, International Journal of Molecular Sciences, 2022, 23(3): 0- 1436 (唯一通讯作者 )
4. Wang, Li-Hong; Zhang, Geng-Lin; Liu, Xing-Yu; Peng, Ai; Ren, Hai-yuan; Wang, Xiao-Jing ; CELSR1 Promotes Neuroprotection in Cerebral Ischemic Injury Mainly Through the Wnt/PKC Signaling Pathway, International Journal of Molecular Sciences, 2020, 21(4): 1267 (唯一通讯作者 )
5. Zhang, G., Wang, L., Liu, X., Zhang, Y., Hu, M., Liu, L., Fang, Y., Mu, Y., Zhao, Y., Huang, S., Liu, T., Wang, X. Cerebral dopamine neurotrophic factor (CDNF) has neuroprotective effects against cerebral ischemia that may occur through the endoplasmic reticulum stress pathway. Int J Mol Sci. 2018 Jun 29;19(7). (通讯作者)
6. Dong, L., Yang, K., Fu, W., Shang, Z., Zhang, Q., Jing, F., Li, L., Xin, H., Wang, X. Gypenosides protected the neural stem cells in the subventricular zone of neonatal rats that were prenatally exposed to ethanol. Int J Mol Sci. 2014 Nov 28; 15(12): 21967-79. (通讯作者)
7. Wang, X. *, Zhang, D. *, Xu, Z., Ma, M., Wang, W., Li, L., Han, X., Huo, Y., Yu, X., Sun, J. Understanding cadherin EGF LAG seven-pass G-type receptors. J Neurochem. 2014 Dec;131(6):699-711. (共同第一作者)
8. Wang, X., Sun, T., Kong, L., Shang, Z., Yang, K., Zhang, Q., Jing, F., Dong, L., Xu, X., Liu, J., Xin, H., Chen, Z. Gypenosides pre-treatment protects the brain against cerebral ischemia and increases neural stem cells/progenitors in the subventricular zone. Int J Dev Neurosci. 2014 Apr;33:49-56.(第一作者)
9. Wang, Y., Kim E., Wang, X., Novitch, B., Yoshikawa, K., Chang, L., Zhu, Y. ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell, 2012, 150: 816-830.
10. Sun, T. *, Wang, X. *, Xie, S., Zhang, D., Wang, X., Li B., Ma, W. and Xin, H. A comparison of proliferative capacity and passaging potential between neural stem and progenitor cells in adherent and neurosphere cultures. Int J Devl Neuroscience, 2011, 29: 723-731. (共同第一作者)
11. Wang, X., Sinn, L., Pollok, K., Sandusky, G., Zhang S., Chen L., Liang, J., Zhang G., Crean, C., Suvannasankha, A., Abonour, R., Sidor, C., Bray, M., Farag S. Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma. Br J Haematol, 2010, 150(3):313-25. (第一作者)
12. Wang, X.*, Hu, Jian.*, Zhao, D. *, Wang, G., Tan, L., Du L., Yang, J., Hou L., Zhang, H., Yu, Y., Zhang, H., Deng, H., Ding, M. NestinnegCD24low/- population from fetal Nestin-EGFP transgenic mice enriches the pancreatic endocrine progenitor cells. Pancreas, 2005, 31(4):385-391. (共同第一作者)
联系方式
济南市文化西路44号教学六楼, 6602室
Email: luckingwang@sdu.edu.cn
电话: 0531-88382046