Bo Chu 初波，Professor
Address: School of Basic Medical Science, Shandong University, Jinan, Shandong, 250012
E-mail: chubo123@sdu.edu.cn
Educational experience:
2015.9– 2019.9: Postdoctoral Research Fellow of Cancer Genetics
Department of Pathology and Cell Biology, Columbia University , USA
2009.9 – 2015.3: Ph.D student of Molecular Cell Biology
Dept. of Life Sciences, University of Science & Technology of China
Supervisor: Prof. Mian Wu
Graduation Date: 2015.3
2005.9 - 2009.7: B.S. Degree in Cell Biology
Dept. of Life Sciences, University of Science & Technology of China
Supervisor: Prof. Jing Liu
Work experience:
2019.10-present: Professor, School of Basic Medical Science, Shandong University
2015.9– 2019.9: Postdoctoral Research Fellow of Cancer Genetics
Department of Pathology and Cell Biology, Columbia University, USA
Research Focus:
铁死亡与代谢
Funding：
1. 国家特支计划青年拔尖人才项目 铁死亡参与耐药肿瘤治疗的机制研究 2024.01-2027.10
2. 科技部重点专项 肿瘤免疫微环境类器官构建和新型治疗策略开发 2022.11-2027.10
3. 国家自然科学基金面上项目 PTEN通过磷脂代谢介导的铁死亡调控前列腺癌发生发展的分子机制研究 2021.01-2026.12
4. 国家自然科学基金青年项目 铁死亡调控神经退行性疾病的分子机制 2021.01-2023.12
5. 山东省自然科学基金杰出青年项目 肿瘤微环境代谢驱动的肿瘤铁死亡可塑性研究 ZR2024JQ019
Awards:
2019.09 泰山学者青年专家 齐鲁青年学者特聘教授
2023.09 国家特支计划青年拔尖人才
2024.09 山东省杰出青年专家
Publications:
1. Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition，Nature Cell Biology，2024， 最后通讯。
2. Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury，Cell Metabolism，2024，最后通讯。
3. Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration，Neuron，2024，共同通讯。
4. S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism，Nature Communications，2025，最后通讯。
5. Structural insights into FSP1 catalysis and ferroptosis inhibition，Nature Communications，2023，共同通讯。
6. Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth，Advanced Science，2023，最后通讯。
7. Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury，Advanced Science，2025，最后通讯
8. Excessive Lipid Peroxidation in Uterine Epithelium Causes Implantation Failure and Pregnancy Loss，Advanced Science，2024，共同通讯
9. Peroxisome-driven ether- linked phospholipids biosynthesis is essential for ferroptosis，Cell death & differentiation，2021，最后通讯
10. Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene，Communications Biology，2023，共同通讯
11. SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation，EMBO Journal，2025，共同通讯
12. Chu Bo, Ning Kon, Delin Chen, Tong Liu, Le Jiang, Shujuan Song, Tongyuan Li, Omid Tavana, and Wei Gu*. Specific Requirement for ALOX12 in p53-mediated Tumor Suppression Reveals A Distinct Pathway of Ferroptosis. Nature cell biology 2019. 21(5):579-591.
13. Chu Bo, Liangwen Zhong, Shuang Dou, Jun Wang, Jianmin Li, Mingwei Wang, Qinghua Shi, Yide Mei, and Mian Wu. miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor[J]. Journal of molecular cell biology, 2015, 7(1): 12-22.
