杨云帆，博士，教授，博士生导师

学习经历：

2009.9-2014.6 南开大学，细胞生物学，博士

2005.9-2009.6 南开大学，生物科学，学士

研究工作经历：

2021.1-至今 山东大学，教授

2020.7-2020.12 美国耶鲁大学，副研究员（Associate Research Scientist）

2015.1-2020.6  美国耶鲁大学，博士后（Postdoc）

研究方向：

1. 脂肪组织介导的环境感知与机体稳态

 肥胖一般是由于人体摄入了过量的营养，这些营养转化为脂肪存储在脂肪组织中引起的。肥胖与II型糖尿病、心血管疾病等慢性疾病和特定类型的癌症等疾病密切相关，为公共健康带来了巨大的负担。本人的主要研究领域之一是脂肪组织的稳态调控及其在代谢类疾病中的功能。具体的研究方向有：

 （1）氧连糖基化修饰在脂肪组织的发育和功能发挥中的作用

 （2）氧连糖基化修饰在脂肪组织免疫微环境中的作用

2. 糖脂代谢物的分子和细胞感知机制

荣誉与奖励：

2020 美国心脏学会，Career Development Award，Top 0.2%

2017 美国心脏学会，Postdoctoral Fellowship

科研项目：

1. 32100948，O-GlcNAc修饰在棕色脂肪血管化中的功能，国家基金委自然科学基金青年项目，2022-01~2024-12，30万，主持

2. 2022YFA0807100，脂肪组织代谢物的感知机制和功能研究，国家重点研发计划青年科学家项目， 2022-12~2027-11，400万元，主持

代表性论文：

1. Yanjie Tan; Zhenzhou Huang; Yi Jin; Jiaying Wang; Hongjun Fan; Yangyang Liu; Liang Zhang; Yue Wu; Peiwei Liu; Tianliang Li; Jie Ran; He Tian; Sin Man Lam; Min Liu; Jun Zhou; Yunfan Yang; Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice, Nature Communications, 2024, 15(1): 8273 (最后通讯)

2. Renjie Hong; Yanjie Tan; Xiaoyu Tian; Zhenzhou Huang; Jiaying Wang; Hua Ni; Jia Yang; Weiwen Bu; Song Yang; Te Li; Fan Yu; Weilong Zhong; Tao Sun; Xiaohong Wang; Dengwen Li; Min Liu; Yunfan Yang; Jun Zhou; XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis, EMBO Reports, 2024, 25(3): 1055-1074 (共通讯)

3. Xiaoyu Tian; Kaiyue Zhang; Renjie Hong; Hanyu Wang; Xifeng Dong; Jun Zhou; Yunfan Yang; Min Liu; Primary cilia restrict autoinflammation by mediating PD-L1 expression, Science Bulletin, 2024, 69(16): 2505-2508 (共通讯)

4. Shuang Sun; Zhaoyang Xu; Haijie Hu; Manxi Zheng; Liang Zhang; Wei Xie; Lei Sun; Peiwei Liu; Tianliang Li; Liangran Zhang; Min Chen; Xueliang Zhu; Min Liu; Yunfan Yang; Jun Zhou; The Bacillus cereus toxin alveolysin disrupts the intestinal epithelial barrier by inducing microtubule disorganization through CFAP100, Science Signaling, 2023, 16(785): eade8111 (共通讯)

5. Yanjie Tan; Yi Jin; Jun Zhou; Yunfan Yang; Lipid droplets in pathogen infection and host immunity, Acta Pharmacologica Sinica, 2023, 45(3): 449-464 (最后通讯)

6. Yunfan Yang^*, Xiruo Li^*, Harding H Luan, Bichen Zhang, Kaisi Zhang, Jin Hyun Nam, Zongyu Li, Minnie Fu, Alexander Munk, Dongyan Zhang, Simeng Wang, Yuyang Liu, João Paulo Albuquerque, Qunxiang Ong, Rui Li, Qi Wang, Marie E Robert, Rachel J Perry, Dongjun Chung, Gerald I Shulman, Xiaoyong Yang. (2020). OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance. Proceedings of the National Academy of Sciences of the United States of America, 117(28):16616-16625. PMID: 32601203

7. Yunfan Yang, Minnie Fu, Min-Dian Li, Kaisi Zhang, Bichen Zhang, Simeng Wang, Yuyang Liu, Weiming Ni, Qunxiang Ong, Jia Mi, Xiaoyong Yang. (2020). O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity. Nature Communications, 11(1):181. PMID: 31924761

8. Yunfan Yang^*, Jie Ran^*, Min Liu, Dengwen Li, Yuanyuan Li, Xingjuan Shi, Dan Meng, Junmin Pan, Guangshuo Ou, Ritu Aneja, Shao-Cong Sun, Jun Zhou. (2014). CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6. Cell Research, 24(11):1342-53. PMID: 25342559

9. Yunfan Yang^*, Min Liu^*, Dengwen Li^*, Jie Ran, Jinmin Gao, Shaojun Suo, Shao-Cong Sun, Jun Zhou. (2014). CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Proceedings of the National Academy of Sciences of the United States of America, 111(6), 2158-2163. PMID: 24469800

联系方式：

地址: 济南市文化西路44号综合楼, 203室

Email: yunfanyang@sdu.edu.cn