近日，我系岳学田研究员的“肿瘤代谢重塑与肿瘤表观遗传”项目获得了2020年度山东省自然科学基金（第一批）项目之优秀青年基金资助；他此前已经入选了“2020年度山东大学齐鲁青年学者”。 岳学田研究员科研工作中不断取得新进展，今年以通讯作者或第一作者及参与发表的SCI文章有六篇。

1: Yu X, Lin Q, Wu Z, Zhang Y, Wang T, Zhao S, Song X, Chen C, Wang Z, Xu L, Li C, Gao L, Liang X, Yue X, Ma C. ZHX2 inhibits SREBP1c-mediated de novo lipogenesis in hepatocellular carcinoma via miR-24-3p. J Pathol. 2020 Dec;252(4):358-370. PMID: 32770671.（共通讯）

2: Wu Z, Ma H, Wang L, Song X, Zhang J, Liu W, Ge Y, Sun Y, Yu X, Wang Z, Wang J, Zhang Y, Li C, Li N, Gao L, Liang X, Yue X, Ma C. Tumor suppressor ZHX2 inhibits NAFLD-HCC progression via blocking LPL-mediated lipid uptake. Cell Death Differ. 2020 May;27(5):1693-1708. PMID: 31740790; PMCID: PMC7206072. （共通讯）

3: Yue X, Wu F, Li Y, Liu J, Boateng M, Mandava K, Zhang C, Feng Z, Gao J, Hu W. Gain of function mutant p53 protein activates AKT through the Rac1 signaling to promote tumorigenesis. Cell Cycle. 2020 Jun;19(11):1338-1351. PMID: 32275841; PMCID: PMC7469461.

4: Yue X, Wu F, Wang J, Kim K, Santhamma B, Dileep KV, Zhang KYJ, Viswanadhapalli S, Vadlamudi RK, Ahmed G, Feng Z, Nickisch K, Hu W. EC330, a small-molecule compound, is a potential novel inhibitor of LIF signaling. J Mol Cell Biol. 2020 Jul 3;12(6):477-480. PMID: 32221559; PMCID: PMC7333478.

5: Liu J, Zhang C, Wu H, Sun XX, Li Y, Huang S, Yue X, Lu SE, Shen Z, Su X, White E, Haffty BG, Hu W, Feng Z. Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression. J Clin Invest. 2020 Jun 1;130(6):3253-3269. PMID: 32478681; PMCID: PMC7260041.

6: Lin Q, Wu Z, Yue X, Yu X, Wang Z, Song X, Xu L, He Y, Ge Y, Tan S, Wang T, Song H, Yuan D, Gong Y, Gao L, Liang X, Ma C. ZHX2 restricts hepatocellular carcinoma by suppressing stem cell-like traits through KDM2A-mediated H3K36 demethylation. EBioMedicine. 2020 Mar;53:102676. PMID: 32114388; PMCID: PMC7047184.

7: Liu W, Wang H, Bai F, Ding L, Huang Y, Lu C, Chen S, Li C, Yue X, Liang X, Ma C, Xu L, Gao L. IL-6 promotes metastasis of non-small-cell lung cancer by up-regulating TIM-4 via NF-κB. Cell Prolif. 2020 Mar;53(3):e12776. PMID: 32020709; PMCID: PMC7106962.

  山东省自然科学基金青年项目旨在进一步提升对青年科研人员的支持，充分发挥省自然科学基金“第一桶金”的作用，同时引导和激励具有一定基础和积累的科研人员冲击更高层次的国家级计划项目，或将更多精力投入应用研究，切实为解决我省企业及产业发展贡献力量。